Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918

This article has now been updated. Please use the final version.

A Case of Bilateral Adrenocortical Adenomas along with Virilization and Cushing's Syndrome
Toshihiro KobayashiHitomi ImachiSeisuke SatoTomohiro IbataKensaku FukunagaTakuo YoshimotoFumi KikuchiKazuko YonezakiNao YamajiJingya LyuTao DongHiromi NagataKyuichi KadotaYoshio KushidaReiji HabaKoji Murao
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JOURNAL OPEN ACCESS Advance online publication

Article ID: 0790-18

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Abstract

We herein present the case of a 27-year-old woman with clinical and biochemical features of virilism. Imaging studies revealed the presence of a bilateral adrenal tumor. Although the secretion of androgens was remarkable, the autonomous production of cortisol was also evident because of a loss of circadian rhythm and the absence of cortisol suppression by dexamethasone. The surgical excision of both adrenal tumors was performed, and the histological examination showed no malignancy. We also report the successful pregnancy and delivery of the patient who showed evolving adrenocortical insufficiency along with virilization and Cushing' s syndrome and who continued to receive glucocorticoid replacement therapy during pregnancy.

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© 2019 by The Japanese Society of Internal Medicine
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