Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Combined Coagulopathy can Induce both Hemorrhagic and Thrombotic Complications in Multiple Myeloma
Ichiro KawashimaKatsuhiro TakanoTakuma KumagaiMegumi KoshiishiSaori OishiYuki SuekiKei NakajimaToru MitsumoriKeita Kirito
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JOURNALS OPEN ACCESS Advance online publication

Article ID: 0915-18


Coagulation abnormalities are a rare but critical complication associated with plasma cell diseases. We herein present a case of multiple myeloma (MM) with complicated coagulopathy. Initially, the patient showed severe bleeding tendency due to concomitant acquired hemophilia A and acquired von Willebrand syndrome. Interestingly, the patient also exhibited hyperactivation of factor IX. During treatment for MM, the bleeding complications were ameliorated; however, the patient had central retinal vein occlusion. All of the coagulation abnormalities were completely resolved after the complete remission of MM. This case suggests that MM patients may have concomitant risks for both bleeding and thromboembolic complications.

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© 2018 by The Japanese Society of Internal Medicine