An Elderly Woman with Complaints of Pain and Hearing Loss, Diagnosed with CMT1A with PMP22 Duplication

Naoki Takegami; Masashi Hamada; Nanaka Yamaguchi-Takegami; Kaori Sakuishi; Tatsushi Toda

doi:10.2169/internalmedicine.1883-23

This article has now been updated. Please use the final version.

An Elderly Woman with Complaints of Pain and Hearing Loss, Diagnosed with CMT1A with PMP22 Duplication

Naoki Takegami, Masashi Hamada, Nanaka Yamaguchi-Takegami, Kaori Sakuishi, Tatsushi Toda

Author information

Keywords: CMT1A, pain, hearing loss, nerve conduction study, PMP22

JOURNAL OPEN ACCESS Advance online publication

Article ID: 1883-23

DOI https://doi.org/10.2169/internalmedicine.1883-23

The final version of this article is now available: Vol. 63 (2024), No. 2 pp. 315-318

Details

Abstract

Charcot-Marie-Tooth (CMT) disease is a heterogeneous hereditary motor and sensory neuropathy of the peripheral nervous system, with CMT1A in particular being the most common form. We encountered a 76-year-old woman with CMT1A who had a history of pain attacks and hearing loss from a young age, with motor symptoms manifesting late in life. Her pain and hearing loss may have been related to CMT. Our case also raises the possibility that neuropathic pain and hearing loss may precede the classic motor symptoms of CMT1A.

Corresponding author

Register with J-STAGE for free!