Detection of Anti-mitochondrial Antibodies Accompanied by Drug-induced Hepatic Injury due to Atorvastatin

Noriyuki Kuniyoshi; Hiroshi Miyakawa; Kotaro Matsumoto; Hiromichi Tsunashima; Katsunori Sekine; Takayuki Tsujikawa; Masatoshi Mabuchi; Shinpei Doi; Kentaro Kikuchi

doi:10.2169/internalmedicine.2708-19

This article has now been updated. Please use the final version.

Detection of Anti-mitochondrial Antibodies Accompanied by Drug-induced Hepatic Injury due to Atorvastatin

Noriyuki Kuniyoshi, Hiroshi Miyakawa, Kotaro Matsumoto, Hiromichi Tsunashima, Katsunori Sekine, Takayuki Tsujikawa, Masatoshi Mabuchi, Shinpei Doi, Kentaro Kikuchi

Author information

Noriyuki Kuniyoshi
Department of Gastroenterology, Teikyo University Mizonokuchi Hospital, Japan
Hiroshi Miyakawa
Fourth Department of Internal Medicine, Teikyo University Mizonokuchi Hospital, Japan
Kotaro Matsumoto
Department of Gastroenterology, Teikyo University Mizonokuchi Hospital, Japan
Hiromichi Tsunashima
Department of Gastroenterology, Teikyo University Mizonokuchi Hospital, Japan
Katsunori Sekine
Department of Gastroenterology, Teikyo University Mizonokuchi Hospital, Japan
Takayuki Tsujikawa
Department of Gastroenterology, Teikyo University Mizonokuchi Hospital, Japan
Masatoshi Mabuchi
Department of Gastroenterology, Teikyo University Mizonokuchi Hospital, Japan
Shinpei Doi
Department of Gastroenterology, Teikyo University Mizonokuchi Hospital, Japan
Kentaro Kikuchi
Fourth Department of Internal Medicine, Teikyo University Mizonokuchi Hospital, Japan

Keywords: statin-induced hepatic injury, drug-induced lymphocyte-stimulation test, anti-mitochondrial antibody

JOURNAL OPEN ACCESS Advance online publication

Article ID: 2708-19

DOI https://doi.org/10.2169/internalmedicine.2708-19

The final version of this article is now available: Vol. 58 (2019), No. 18 pp. 2663-2667

Details

Abstract

A 44-year-old Japanese woman was admitted to our hospital with fatigue and an altered liver function. She had been receiving atorvastatin treatment for 10 months. Although no jaundice was seen, the patient's serum alkaline phosphatase and γ-glutamyl transpeptidase levels were markedly elevated. Based on the results of a drug-induced lymphocyte-stimulation test, her liver disease was diagnosed as atorvastatin-induced hepatic injury. Subsequently, anti-mitochondrial antibodies (AMAs) were detected in her serum; however, a liver biopsy specimen did not show the characteristic features of primary biliary cholangitis. We herein report the detection of AMAs accompanied by drug-induced hepatic injury caused by atorvastatin.

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