Hereditary Antithrombin Deficiency Presenting with Deep Venous Thrombosis During the Second Pregnancy: A Case Report

Motoki Yamashita; Tomo Komaki; Kohei Tashiro; Yuki Inada; Atsushi Iwata; Masahiro Ogawa; Eriko Morishita; Shin-ichiro Miura

doi:10.2169/internalmedicine.3268-19

This article has now been updated. Please use the final version.

Hereditary Antithrombin Deficiency Presenting with Deep Venous Thrombosis During the Second Pregnancy: A Case Report

Motoki Yamashita, Tomo Komaki, Kohei Tashiro, Yuki Inada, Atsushi Iwata, Masahiro Ogawa, Eriko Morishita, Shin-ichiro Miura

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Keywords: hereditary antithrombin deficiency, deep venous thrombosis, negative family history of thrombosis

JOURNAL OPEN ACCESS Advance online publication

Article ID: 3268-19

DOI https://doi.org/10.2169/internalmedicine.3268-19

The final version of this article is now available: Vol. 59 (2020), No. 2 pp. 235-239

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Abstract

A 37-year-old woman developed deep venous thrombosis (DVT) of the left lower extremity at 8 weeks of gestation during her second pregnancy. There was no personal or family history of thrombosis. She received intravenous heparin, but heparin resistance was noted. The plasma antithrombin activity decreased to 45% in the acute phase, and it remained low postpartum. Her mother also had low plasma antithrombin activity (46%), and genetic testing revealed a heterozygous SERPINC1 mutation. Even without a family history of thrombosis, we should suspect hereditary antithrombin deficiency in patients with initial DVT and perform thorough investigation.

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