Successful Antibiotic Treatment of Phlegmonous Gastritis Following Allogeneic Hematopoietic Stem Cell Transplantation

Kyoko Masuda; Masatoshi Sakurai; Yuka Shiozawa; Miki Sakamoto; Takahide Shindo; Ami Inokuchi; Hiroyoshi Hayashi; Yuya Koda; Hiromasa Nagata; Jun Kato; Keisuke Kataoka

doi:10.2169/internalmedicine.4830-24

Kyoko Masuda, Masatoshi Sakurai, Yuka Shiozawa, Miki Sakamoto, Takahide Shindo, Ami Inokuchi, Hiroyoshi Hayashi, Yuya Koda, Hiromasa Nagata, Jun Kato, Keisuke Kataoka

Author information

Kyoko Masuda
Division of Hematology, Department of Medicine, Keio University School of Medicine, Japan
Masatoshi Sakurai
Division of Hematology, Department of Medicine, Keio University School of Medicine, Japan
Yuka Shiozawa
Division of Hematology, Department of Medicine, Keio University School of Medicine, Japan
Miki Sakamoto
Division of Hematology, Department of Medicine, Keio University School of Medicine, Japan
Takahide Shindo
Division of Hematology, Department of Medicine, Keio University School of Medicine, Japan
Ami Inokuchi
Division of Hematology, Department of Medicine, Keio University School of Medicine, Japan
Hiroyoshi Hayashi
Division of Hematology, Department of Medicine, Keio University School of Medicine, Japan
Yuya Koda
Division of Hematology, Department of Medicine, Keio University School of Medicine, Japan
Hiromasa Nagata
Department of Anesthesiology, Keio University School of Medicine, Japan
Jun Kato
Division of Hematology, Department of Medicine, Keio University School of Medicine, Japan
Keisuke Kataoka
Division of Hematology, Department of Medicine, Keio University School of Medicine, Japan
Division of Molecular Oncology, National Cancer Center Research Institute, Japan

Keywords: phlegmonous gastritis, bone marrow transplantation, aplastic anemia, antibiotics

JOURNAL OPEN ACCESS Advance online publication

Article ID: 4830-24

DOI https://doi.org/10.2169/internalmedicine.4830-24

Details

Abstract

Phlegmonous gastritis (PG) is a rare, life-threatening bacterial infection characterized by thickening of the gastric wall. We report a case of PG in a 17-year-old male following allogeneic hematopoietic stem cell transplantation for severe aplastic anemia. Seven months after transplantation, the patient presented with severe abdominal pain, fever, and significant gastric wall thickening on CT. Initial antibiotic therapy was initiated immediately. The patient developed multiple organ failure; however, his condition rapidly improved with intensive care. After two weeks, the patient improved and was successfully discharged. This is the first report of PG after transplantation, highlighting the need for an early diagnosis and treatment.

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