A Severe Case of Rhabdomyolysis Requiring Renal Replacement Therapy Following COVID-19 mRNA Vaccination

Motohiro Ueda; Kohei Uchimura; Kie Ohkoshi; Natsumi Saegusa; Keiichi Osano; Shun Yoshida; Makiko Konishi; Toshihisa Ishii; Kazuya Takahashi; Ayumu Nakashima

doi:10.2169/internalmedicine.4835-24

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引用する場合も本公開記事を引用してください。

A Severe Case of Rhabdomyolysis Requiring Renal Replacement Therapy Following COVID-19 mRNA Vaccination

Motohiro Ueda, Kohei Uchimura, Kie Ohkoshi, Natsumi Saegusa, Keiichi Osano, Shun Yoshida, Makiko Konishi, Toshihisa Ishii, Kazuya Takahashi, Ayumu Nakashima

著者情報

Motohiro Ueda
Department of Nephrology, Graduate School of Medicine, University of Yamanashi, Japan
Kohei Uchimura
Department of Nephrology, Graduate School of Medicine, University of Yamanashi, Japan
Kie Ohkoshi
Department of Nephrology, Graduate School of Medicine, University of Yamanashi, Japan
Natsumi Saegusa
Department of Nephrology, Graduate School of Medicine, University of Yamanashi, Japan
Keiichi Osano
Department of Nephrology, Graduate School of Medicine, University of Yamanashi, Japan
Shun Yoshida
Department of Nephrology, Graduate School of Medicine, University of Yamanashi, Japan
Makiko Konishi
Department of Nephrology, Graduate School of Medicine, University of Yamanashi, Japan
Toshihisa Ishii
Department of Nephrology, Graduate School of Medicine, University of Yamanashi, Japan
Kazuya Takahashi
Department of Nephrology, Graduate School of Medicine, University of Yamanashi, Japan
Ayumu Nakashima
Department of Nephrology, Graduate School of Medicine, University of Yamanashi, Japan

キーワード: Rhabdomyolysis, mRNA vaccine, COVID-19, Acute Kidney Injury, Online Hemodiafiltration, Statin

ジャーナルオープンアクセス早期公開

論文ID: 4835-24

DOI https://doi.org/10.2169/internalmedicine.4835-24

この記事には本公開記事があります。

The final version of this article is now available: Vol. 64 (2025), No. 10 pp. 1547-1551

詳細

抄録

A 60-year-old man who developed rhabdomyolysis and severe acute kidney injury (AKI) after the fourth COVID-19 mRNA vaccination, necessitating renal replacement therapy (RRT). The patient presented to the hospital two days post-vaccination with muscle pain in both lower extremities and anuria. Diagnostic tests revealed elevated creatinine kinase (CK) levels of 160,000 IU/L and serum creatinine levels of 6.59 mg/dL, confirming AKI due to rhabdomyolysis. Intravenous therapy was ineffective, leading to the utilization of online hemodiafiltration. Following treatment, CK levels normalized, and the renal function fully recovered.

責任著者(Corresponding author)

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