Spontaneous Muscle Hematoma in Japanese Patients with Severe COVID-19 Treated with Unfractionated Heparin: Two Case Reports

Yu Ito; Nobuyasu Awano; Fumiya Uchiyama; Minoru Inomata; Naoyuki Kuse; Mari Tone; Kohei Takada; Kazushi Fujimoto; Yutaka Muto; Shogo Sagisaka; Kenro Maki; Ryuta Yamashita; Akinori Harada; Jun-ichi Nishimura; Munehiro Hayashi; Takehiro Izumo

doi:10.2169/internalmedicine.7422-21

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引用する場合も本公開記事を引用してください。

Spontaneous Muscle Hematoma in Japanese Patients with Severe COVID-19 Treated with Unfractionated Heparin: Two Case Reports

Yu Ito, Nobuyasu Awano, Fumiya Uchiyama, Minoru Inomata, Naoyuki Kuse, Mari Tone, Kohei Takada, Kazushi Fujimoto, Yutaka Muto, Shogo Sagisaka, Kenro Maki, Ryuta Yamashita, Akinori Harada, Jun-ichi Nishimura, Munehiro Hayashi, Takehiro Izumo

著者情報

Yu Ito
Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan
Nobuyasu Awano
Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan
Fumiya Uchiyama
Department of Interventional Radiology, Japanese Red Cross Medical Center, Japan
Minoru Inomata
Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan
Naoyuki Kuse
Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan
Mari Tone
Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan
Kohei Takada
Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan
Kazushi Fujimoto
Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan
Yutaka Muto
Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan
Shogo Sagisaka
Department of Emergency and Critical Care Medicine, Japanese Red Cross Medical Center, Japan
Kenro Maki
Department of Emergency and Critical Care Medicine, Japanese Red Cross Medical Center, Japan
Ryuta Yamashita
Department of Emergency and Critical Care Medicine, Japanese Red Cross Medical Center, Japan
Akinori Harada
Department of Interventional Radiology, Japanese Red Cross Medical Center, Japan
Jun-ichi Nishimura
Department of Interventional Radiology, Japanese Red Cross Medical Center, Japan
Munehiro Hayashi
Department of Emergency and Critical Care Medicine, Japanese Red Cross Medical Center, Japan
Takehiro Izumo
Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan

キーワード: COVID-19, spontaneous muscle hematoma, therapeutic anticoagulation, vascular dysfunction, unfractionated heparin, case report

ジャーナルオープンアクセス早期公開

論文ID: 7422-21

DOI https://doi.org/10.2169/internalmedicine.7422-21

この記事には本公開記事があります。

The final version of this article is now available: Vol. 60 (2021), No. 21 pp. 3503-3506

詳細

抄録

In hospitalized coronavirus disease 2019 (COVID-19) patients, anticoagulation therapy is administered to prevent thrombosis. However, anticoagulation sometimes causes bleeding complications. We herein report two Japanese cases of severe COVID-19 in which spontaneous muscle hematomas (SMH) developed under therapeutic anticoagulation with unfractionated heparin. Although the activated partial prothrombin time was within the optimal range, contrast-enhanced computed tomography (CECT) revealed SMH in the bilateral iliopsoas muscles in both cases, which required emergent transcatheter embolization. Close monitoring of the coagulation system and the early diagnosis of bleeding complications through CECT are needed in severe COVID-19 patients treated with anticoagulants.

責任著者(Corresponding author)

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