Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918

This article has now been updated. Please use the final version.

A Case of Repeated Necrotizing Lymphadenitis with MEFV Gene Mutations
Yuta YamamuraKengo FuruichiTadashi ToyamaMegumi OshimaHisayuki OguraKoichi SatoShiori NakagawaTaro MiyagawaShinji KitajimaAkinori HaraYasunori IwataNorihiko SakaiMiho ShimizuHiroko IkedaTomoko TomaKazuya TakasawaAkihiro YachieTakashi Wada
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JOURNAL OPEN ACCESS Advance online publication

Article ID: 7882-21

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Abstract

We herein report a 36-year-old man with repeated necrotizing lymphadenitis due to MEFV gene mutations. The patient's chief complaints were a fever and painful cervical lymphadenopathy. We diagnosed him with necrotizing lymphadenitis based on the pathological findings of the lymph nodes and the exclusion of other differential diseases. The same episode recurred four times. We speculated the involvement of autoinflammatory backgrounds and detected MEFV gene mutations of E148Q (homo), P369S, and R408Q. Considering the elevation of interleukin-18, these mutations probably played roles in the repeated necrotizing lymphadenitis.

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© 2022 by The Japanese Society of Internal Medicine
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