Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Sclerosing Esophagitis with IgG4-positive Plasma Cell Infiltration: A Case Report
Shigeo MoriYoshiya TahashiKazushige UchidaTsukasa IkeuraNaoyuki DanbaraTakahiro WakamatsuTakeo KusudaYu TakahashiMasato YanagawaMitsunobu MatsushitaChisato OheTaku MichiuraKentaro InoueMasanori KonKazuichi Okazaki
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JOURNALS OPEN ACCESS Advance online publication

Article ID: 8095-16


The patient was a 76-year-old woman who had noticed slight difficulty in swallowing in the 3 years prior to this presentation. Her dysphagia progressed while she was hospitalized following cervical cancer surgery. Esophagogastroduodenoscopy and an esophagram showed circumferential erosion and a stricture of the thoracic esophagus. Esophageal resection was performed; the resected specimens showed a stricture and wall thickening. Histologically, transmural hyperplasia, which consisted of inflammatory granulation tissue with the abundant infiltration of IgG4-positive plasma cells and lymphocytes, was observed. The patient was diagnosed with probable IgG4-related disease. IgG4-related esophageal disease presenting as esophageal lesions alone is a very rare condition.

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© 2017 by The Japanese Society of Internal Medicine