A Case of Seronegative Full-house Nephropathy with Crohn's Disease

Hideki Uedono; Akihiro Tsuda; Noriko Ueno; Yuka Natsuki; Rino Nakaya; Kozo Nishide; Yuri Machiba; Kenta Fujimoto; Shinya Nakatani; Katsuhito Mori; Masanori Emoto

doi:10.2169/internalmedicine.8820-21

This article has now been updated. Please use the final version.

A Case of Seronegative Full-house Nephropathy with Crohn's Disease

Hideki Uedono, Akihiro Tsuda, Noriko Ueno, Yuka Natsuki, Rino Nakaya, Kozo Nishide, Yuri Machiba, Kenta Fujimoto, Shinya Nakatani, Katsuhito Mori, Masanori Emoto

Author information

Hideki Uedono
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan
Akihiro Tsuda
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan
Noriko Ueno
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan
Yuka Natsuki
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan
Rino Nakaya
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan
Kozo Nishide
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan
Yuri Machiba
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan
Kenta Fujimoto
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan
Shinya Nakatani
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan
Katsuhito Mori
Department of Nephrology Medicine, Osaka City University Graduate School of Medicine, Japan
Masanori Emoto
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan
Department of Nephrology Medicine, Osaka City University Graduate School of Medicine, Japan

Keywords: full-house nephropathy, Crohn's disease, IgA nephropathy

JOURNAL OPEN ACCESS Advance online publication

Article ID: 8820-21

DOI https://doi.org/10.2169/internalmedicine.8820-21

The final version of this article is now available: Vol. 61 (2022), No. 23 pp. 3553-3558

Details

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease. Lupus nephritis (LN) is a major risk factor for mortality in SLE, and glomerular "full-house" immunofluorescence staining is a well-known characteristic of LN. However, some cases of non-lupus glomerulonephritis can also present with a "full-house" immunofluorescence pattern. We recently encountered a patient with full-house nephropathy (FHN) during adalimumab administration for Crohn's disease. IgA nephropathy or idiopathic FHN was diagnosed, and treatment with steroids was started, after which there was improvement in proteinuria. The prognosis of FHN has been reported to be poor; therefore, aggressive treatment is required for such patients.

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