Amiodarone-induced Thyrotoxicosis with Cardiopulmonary Arrest

Kosuke Inoue; Jun Saito; Tetsuo Kondo; Kaoru Miki; Chiho Sugisawa; Yuya Tsurutani; Naoki Hasegawa; Shinya Kowase; Yukio Kakuta; Masao Omura; Tetsuo Nishikawa

doi:10.2169/internalmedicine.9177-17

This article has now been updated. Please use the final version.

Amiodarone-induced Thyrotoxicosis with Cardiopulmonary Arrest

Kosuke Inoue, Jun Saito, Tetsuo Kondo, Kaoru Miki, Chiho Sugisawa, Yuya Tsurutani, Naoki Hasegawa, Shinya Kowase, Yukio Kakuta, Masao Omura, Tetsuo Nishikawa

Author information

Kosuke Inoue
Endocrinology and Diabetes Center, Yokohama Rosai Hospital, Japan
Jun Saito
Endocrinology and Diabetes Center, Yokohama Rosai Hospital, Japan
Tetsuo Kondo
Department of Human Pathology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, Japan
Kaoru Miki
Departments of Endocrinology and Diabetes, JCHO Tokyo Yamate Medical Center, Japan
Chiho Sugisawa
Endocrinology and Diabetes Center, Yokohama Rosai Hospital, Japan
Yuya Tsurutani
Endocrinology and Diabetes Center, Yokohama Rosai Hospital, Japan
Naoki Hasegawa
Department of Pathology, Yokohama Rosai Hospital, Japan
Shinya Kowase
Department of Cardiovascular Medicine, Yokohama Rosai Hospital, Japan
Yukio Kakuta
Department of Pathology, Yokohama Rosai Hospital, Japan
Masao Omura
Endocrinology and Diabetes Center, Yokohama Rosai Hospital, Japan
Tetsuo Nishikawa
Endocrinology and Diabetes Center, Yokohama Rosai Hospital, Japan

Keywords: Amiodarone-induced thyrotoxicosis, Hyperthyroxinemia, Cardiopulmonary arrest, Prednisolone, Thyroidectomy

JOURNAL OPEN ACCESS Advance online publication

Article ID: 9177-17

DOI https://doi.org/10.2169/internalmedicine.9177-17

The final version of this article is now available: Vol. 57 (2018), No. 1 pp. 59-63

Details

Abstract

We describe a case of amiodarone-induced thyrotoxicosis (AIT) with cardiopulmonary arrest (CPA) in a 49-year-old woman. The patient had been treated with amiodarone for non-sustained ventricular tachycardia. Two weeks prior to her admission, she developed thyrotoxicosis and prednisolone (PSL, 30 mg daily) was administered with the continuation of amiodarone. However, she was admitted to our hospital for CPA. We performed total thyroidectomy to control her thyrotoxicosis and the pathological findings were consistent with type 2 AIT. She gradually improved and was discharged on day 84. This case demonstrates the importance of considering immediate total thyroidectomy for patients with uncontrollable AIT.

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