Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918

This article has now been updated. Please use the final version.

A Case Report of FLAMES with Elevated Myelin Basic Protein Followed by Myelitis
Hiroyuki HokamaYuki SakamotoToshiyuki HayashiSeira HatakeMizuho TakahashiHiroto KoderaAkihito KutsunaChikako NitoShunya NakaneHiroshi NagayamaToshiyuki TakahashiKazumi Kimura
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JOURNAL OPEN ACCESS Advance online publication

Article ID: 9439-22

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Abstract

The pathophysiology of unilateral cortical fluid-attenuated inversion recovery (FLAIR)-hyperintense lesions in anti-myelin oligodendrocyte glycoprotein (MOG)-associated encephalitis with seizures (FLAMES) is unclear. A 26-year-old man was referred because of a seizure. FLAIR showed an increased signal intensity and swelling of the right frontal cortex. His symptoms and imaging abnormalities were improved after intravenous methylprednisolone therapy. MOG antibody was detected both in serum and cerebrospinal fluid (CSF). Therefore, the patient was diagnosed with FLAMES. Myelin basic protein (MBP) was elevated in CSF. The high MBP value in the CSF in the present case suggested that demyelination as well as inflammation can occur in some FLAMES patients.

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© 2022 by The Japanese Society of Internal Medicine
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