A Case of IgA Nephropathy after Nivolumab Therapy for Postoperative Recurrence of Lung Squamous Cell Carcinoma

Seiji Kishi; Masanori Minato; Atsuro Saijo; Naoka Murakami; Masanori Tamaki; Motokazu Matsuura; Taichi Murakami; Kojiro Nagai; Hideharu Abe; Yasuhiko Nishioka; Toshio Doi

doi:10.2169/internalmedicine.9814-17

この記事には本公開記事があります。本公開記事を参照してください。
引用する場合も本公開記事を引用してください。

A Case of IgA Nephropathy after Nivolumab Therapy for Postoperative Recurrence of Lung Squamous Cell Carcinoma

Seiji Kishi, Masanori Minato, Atsuro Saijo, Naoka Murakami, Masanori Tamaki, Motokazu Matsuura, Taichi Murakami, Kojiro Nagai, Hideharu Abe, Yasuhiko Nishioka, Toshio Doi

著者情報

Seiji Kishi
Department of Nephrology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Masanori Minato
Department of Nephrology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Atsuro Saijo
Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Naoka Murakami
Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, MA, USA
Masanori Tamaki
Department of Nephrology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Motokazu Matsuura
Department of Nephrology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Taichi Murakami
Department of Nephrology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Kojiro Nagai
Department of Nephrology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Hideharu Abe
Department of Nephrology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Yasuhiko Nishioka
Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Toshio Doi
Department of Nephrology, Graduate School of Biomedical Sciences, Tokushima University, Japan

キーワード: nivolumab, onconephrology, immune-related adverse events (irAEs), glomerular injury, IgA nephropathy

ジャーナルオープンアクセス早期公開

論文ID: 9814-17

DOI https://doi.org/10.2169/internalmedicine.9814-17

この記事には本公開記事があります。

The final version of this article is now available: Vol. 57 (2018), No. 9 pp. 1259-1263

詳細

抄録

Immune checkpoint inhibitors (ICIs) are becoming a common and important cancer therapy. ICIs are associated with a unique category of side effects, termed immune-related adverse events (irAEs).

We herein report the case of a 72-year-old man with postoperative recurrence of lung squamous cell carcinoma who was treated with nivolumab and who developed proteinuria and a worsening kidney function. A kidney biopsy revealed IgA nephropathy. After drug withdrawal, the proteinuria improved and the deterioration of the patient's renal function was halted. Although renal irAEs are considered to be rare and glomerulonephritis is not typical presentation, physicians need to pay more attention to renal irAEs and glomerular injury.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）