1976 年 15 巻 2 号 p. 139-145
An autopsy case of primary acquired sideroblastic anemia (PASA) is described. Cytogenetic studies showed an isochromosome 17 (17qi) not only in diploid but also in octaploid cells from the bone marrow, whereas the karyo-type of peripheral lymphocytes was normal. Postmortem examinations revealed hyperplasia of the three myeloid cell lines in the bone marrow and extramedullary hematopoiesis in the liver and spleen, but no evidence of leukemia. The present case provides cytogenetic evidence that PASA is a disorder derived from an uncommitted stem cell mutation and is clonal in nature.
