A Case of an Lactate Dehydrogenase (LDH)-IgG Complex Formation which Causes Low Plasma LDH Activity and an Abnormal LDH Isozyme Pattern

Abstract

A case of an LDH-IgG complex formation which causes low plasma LDH activity and an abnormal LDH isozyme pattern was reported. A patient had pericarditis and myocardial hypertrophy of asymmetrical septal hypertrophy type. The same IgG was recognized in pericardial effusion. From a column chromatographic study, the molecular weight of LDH-IgG complex was estimated as being about 490, 000. This complex was speculated as the IgG₁ -LDH₂. The mechanism by which LDH-IgG is formed and the relationship between the complex itself and cardiac diseases remain unknown.