Influence of Serum Protein Levels on Serum Fructosamine Levels

Abstract

The serum fructosamine level is influenced by the serum protein level. Therefore, we investigated the relationship between serum fructosamine levels and serum total protein and albumin levels measured simultaneously in non-diabetic and diabetic patients. Significant positive correlations were found between them. A correction formula was constructed to express the serum fructosamine level when the serum total protein level was 7 g/dl or when the serum albumin level was 4 g/dl: corrected fructosamine (mmol/l) = measured fructosamine (mmol/l) + A (7 (g/dl) or 4 (g/dl) - serum total protein (g/dl) or serum albumin (g/dl)) where A is 0.28 for serum total protein and 0.30 for serum albumin in non-diabetic subjects; 0.29 for serum total protein and 0.35 for serum albumin in diabetic patients; and 0.29 for serum total protein and 0.31 for serum albumin in non-diabetic and diabetic subjects combined.