Japanese Journal of Medicine
Online ISSN : 1881-123X
Print ISSN : 0021-5120
Carnitine Deficiency Following Massive Intestinal Resection: A Morphological and Biochemical Study
Hiroaki MIYAJIMAMasanobu SAKAMOTOTetsurou OIKAWAHiromi HONJOUShigeru KANAOKANishio HONDA
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1990 Volume 29 Issue 1 Pages 95-98

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Abstract

A 65-year-old man with progressive muscle weakness and liver dysfunction following massive small bowel resection showed myriad lipid-filled vacuoles in type I muscle fibers. Carnitine was significantly decreased in muscle, serum and urine. Carnitine supplementation was followed by clinical improvement and decreased lipid droplets in biopsied muscle. He had been receiving carnitine-deficient total parenteral nutrition. This form of carnitine deficiency may be due to a defect in carnitine biosynthesis, as well as dietary carnitine deficiency.

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© The Japanese Society of Internal Medicine
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