Japanese Journal of Medicine
Online ISSN : 1881-123X
Print ISSN : 0021-5120
Successful Treatment of a Patient with Posthepatitic Severe Aplastic Anemia with Bolus Methylprednisolone
Shuji TOHDAToshiya SUZUKIKaoru NAGATANobuo NARANobuo AOKI
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1990 Volume 29 Issue 2 Pages 191-194

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Abstract

A 31-year-old female developed severe aplastic anemia following acute non-A non-B hepatitis. Because of the impossibility of bone marrow transplantation, bolus methylprednisolone therapy was done. Soon after the therapy, pancytopenia improved. She has since taken mepitiostane and no longer needs blood transfusions. Good response to the immunosuppressive therapy suggests that the pathogenesis of this anemia is related to the immune system. In vitro culture demonstrated that the patient's serum contained a factor which suppressed hematopoietic activity, possibly gamma-interferon.

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© The Japanese Society of Internal Medicine
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