Abstract
The clotting activity of platelet, called platelet factor 3 which may be liberated from platelet during the process of its physical changes, referred to as viscous metamorphosis, would seem to be most important, and its intrinsic thromboplastin generation activity is probably related to its phospholipid contents. It has been shown that phospholipid derived from sources other than platelets can act as fairly efficient substitutes for platelet in the thromboplastin generation1, 2). Recent investigations have been directed to study phospholipid components of human platelets and their effects in blood clotting. However, the results have shown a good deal of disagreement. While, the morphological changes of platelets as corpuscles in clotting process, have been much investigated but little is known about the nature of the surface of platelet, which is likely concerned with the aggregation or adhesion of platelets and absorption of protein. In this paper, attempt was made to analyse the chemical constituents of platelet phospholipid and compare their clotting activities and clarify the nature of the surface of platelet.
