Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
The Level of Serum Granulocyte Colony-Stimulating Factor in Cancer Patients with Leukocytosis
Akemi KUBO SHIMASAKIKyoji HIRATATetsuji KAWAMURANobuya KUNIBEKenzo HIRAIKenrou YOSHIMOTOHisako HASHIMOTOYasuharu NAKAHARAYoshirou MOCHIZUKI
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1992 Volume 31 Issue 7 Pages 861-865

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Abstract

The level of serum granulocyte colony-stimulating factor (G-CSF) obtained from patients with leukocytosis (>10, 000/μl) between May 1989 and April 1991 was measured by enzyme immunoassay. Studied were 18 patients with malignant neoplasms (median age, 64 years) and 14 patients with hematologic disease (median age, 59 years). Increased serum G-CSF values ranging from 70 to 374pg/ml were noted in 7 of 15 lung cancer cases, a case of malignant thymoma and a blastic crisis of chronic myelogenous leukemia. The rest of the cases showed a normal value (<60 pg/ml). There was no correlation between the neutrophil count and G-CSF level. In lung cancer cases with high G-CSF values, neither a characteristic histologic type nor common elevation of tumor markers could be seen. The neutrophil alkaline phosphatase score was significantly increased and hypercalcemia was presented in high G-CSF cases. G-CSF may contribute at least in part to unknown leukocytosis observed in malignant neoplasms, especially in lung cancer.
(Internal Medicine 31 : 861-865, 1992)

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© The Japanese Society of Internal Medicine
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