Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Type 1 (Insulin-Dependent) Diabetes Mellitus with Coexisting Autoimmune Thyroid Disease in Japan
Nobuhiro CHIKUBAShoichi AKAZAWAYoshihiko YAMAGUCHIEiji KAWASAKIHirofumi TAKINOYukio TAKAOYasuo MAEDAShinichiro OKUNOHidefumi YAMAMOTOAtsushi YOKOTAMasaaki YOSHIMOTOShigenobu NAGATAKI
Author information
JOURNALS FREE ACCESS

1992 Volume 31 Issue 9 Pages 1076-1080

Details
Abstract

Type 1 diabetes mellitus is known to be a heterogenous disease which is frequently complicated with other autoimmune thyroid diseases (AITD). The present study was designed to investigate the clinical characteristics and HLA antigens in Japanese Type 1 diabetic patients with AITD. Subjects were 25 Type 1 diabetic patients with AITD (13 Graves' disease and 12 Hashimoto's thyroiditis) and 32 Type 1 diabetic patients without AITD. Compared with Type 1 diabetic patients without AITD, age at onset of diabetes was later and positive ICA persisted much longer in the diabetic patients with AITD. Compared with normal controls, DR9 was increased in the patients with AITD, while DR4 was increased in those without AITD. Type 1 diabetic patients with AITD were characterized by the late onset of diabetes, persistent ICA and increased association with DR9. These results suggest that immunological and genetic heterogeneity may exist within Japanese Type 1 diabetic patients.
(Internal Medicine 31 : 1076-1080, 1992)

Information related to the author
© The Japanese Society of Internal Medicine
Previous article Next article
feedback
Top