Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Remarkable Increase in CD26-Positive T Cells in Patients with Human T Lymphotropic Virus Type I (HTLV-I) Associated Myelopathy
Kohji SHIBAYAMATatsufumi NAKAMURAIkuo KINOSHITAYukitaka UEKIHideto NAKAOKatsumi EGUCHIMitsuhiro TSUJIHATAShigenobu NAGATAKI
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1992 Volume 31 Issue 9 Pages 1081-1083

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Abstract

We used two-color flow cytometric analysis to investigate CD26+ (Ta1+) cells in peripheral blood T lymphocytes from patients with human T-lymphotropic virus type-I (HTLV-I) - associated myelopathy (HAM). The percentage of CD26+ cells among CD3+ cells was markedly increased in patients with HAM, compared with anti-HTLV-I seropositive carriers (p<0.001) and seronegative controls (p<0.01). Within the subpopulation of T cells, a significantly high percentage of CD26+ cells was detected in both CD4+ and CD8+ cell populations. Furthermore, analysis of HLA-DR+T cells revealed similar results. In contrast CD4+CD45RA+ cells were significantly decreased in comparison with controls. These results suggest that immunologically activated or memory T cells found in peripheral blood may be etiologically relevant to HAM.
(Internal Medicine 31 : 1081-1083, 1992)

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