Wegener's Granulomatosis in a Patient with a Rheumatoid Arthritis

Hiroyuki OHASHI; Mitsuyasu ITOH; Noriyoshi OGAWA; Yuichiro SUDO; Shigeki ENDO; Tadamasa OKUGAWA; Hisako ITO; Hiroyuki MINETA; Michihiko NOZUE

doi:10.2169/internalmedicine.31.1128

Hiroyuki OHASHI, Mitsuyasu ITOH, Noriyoshi OGAWA, Yuichiro SUDO, Shigeki ENDO, Tadamasa OKUGAWA, Hisako ITO, Hiroyuki MINETA, Michihiko NOZUE

Author information

Hiroyuki OHASHI
the Third Department of Internal Medicine, Hamamatsu University School of Medicine
Mitsuyasu ITOH
the Third Department of Internal Medicine, Hamamatsu University School of Medicine
Noriyoshi OGAWA
the Third Department of Internal Medicine, Hamamatsu University School of Medicine
Yuichiro SUDO
the Third Department of Internal Medicine, Hamamatsu University School of Medicine
Shigeki ENDO
the Third Department of Internal Medicine, Hamamatsu University School of Medicine
Tadamasa OKUGAWA
the Third Department of Internal Medicine, Hamamatsu University School of Medicine
Hisako ITO
the Department of Otorhinolaryngology, Hamamatsu University School of Medicine
Hiroyuki MINETA
the Department of Otorhinolaryngology, Hamamatsu University School of Medicine
Michihiko NOZUE
the Department of Otorhinolaryngology, Hamamatsu University School of Medicine

Keywords: granuloma, rheumatoid factor, ankylosis, immune complex, cyclophosphamide

JOURNAL FREE ACCESS

1992 Volume 31 Issue 9 Pages 1128-1131

DOI https://doi.org/10.2169/internalmedicine.31.1128

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Abstract

A 38-year-old woman with rheumatoid arthritis who developed Wegener's granulomatosis is described. Wegener's granulomatosis appeared with saddle nose, perforation in her nasal septum, and granuloma in the nasal cavity. Laboratory evaluation showed a positive rheumatoid factor and circulating immune complex. Radiographic examination revealed ankylotic changes in both wrist and elbow joints. Bilateral anosmia and other disease manifestations completely responded to treatment with oral cyclophosphamide and prednisolone.
(Internal Medicine 31 : 1128-1131, 1992)

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