Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Bleeding Tendency Caused by the Deposit of Amyloid Substance in the Perivascular Region
Yoshiaki HOSHINOKiyohiko HATAKEKazuo MUROISaburo TSUNODAToshiyuki SUZUKIAkiyoshi MIWAShinobu SAKAMOTOYasusada MIURA
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1993 Volume 32 Issue 11 Pages 879-881


A 55-year-old woman, who had systemic amyloidosis associated with multiple myeloma, had sudden development of hematomas of her lip and upper eye lid. There was no evidence of deterioration of multiple myeloma, thrombocytopenia nor deficiency of coagulation factors. Biopsy specimen showed the deposit of amyloid substance in the dermis and perivascular region. The bleeding tendency in this patient with myeloma was likely due to the deposit of amyloid substance in the vascular wall; improvement was achieved with administration of hemostatic agents.
(Internal Medicine 32: 879-881-1993)

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