Distinct Responses of Interleukin-6 and Other Laboratory Parameters to Treatment in a Patient with Wegener's Granulomatosis

Hajime NAKAHAMA; Tomoko YOKOKAWA; Mitsunori OKADA; Mutsuo MIYAZAKI; Nobuyuki IMAI; Shujiro KUBORI; Takeshi NAKANISHI; Osamu UYAMA; Minoru SUGITA

doi:10.2169/internalmedicine.32.189

Hajime NAKAHAMA, Tomoko YOKOKAWA, Mitsunori OKADA, Mutsuo MIYAZAKI, Nobuyuki IMAI, Shujiro KUBORI, Takeshi NAKANISHI, Osamu UYAMA, Minoru SUGITA

Author information

Hajime NAKAHAMA
the Fifth Department of Internal Medicine, Hyogo College of Medicine
Tomoko YOKOKAWA
the Department of Medicine, Kansai Rosai Hospital
Mitsunori OKADA
the Department of Medicine, Kansai Rosai Hospital
Mutsuo MIYAZAKI
the Department of Medicine, Kansai Rosai Hospital
Nobuyuki IMAI
the Department of Medicine, Kansai Rosai Hospital
Shujiro KUBORI
the Department of Medicine, Kansai Rosai Hospital
Takeshi NAKANISHI
the Fifth Department of Internal Medicine, Hyogo College of Medicine
Osamu UYAMA
the Fifth Department of Internal Medicine, Hyogo College of Medicine
Minoru SUGITA
the Fifth Department of Internal Medicine, Hyogo College of Medicine

Keywords: cyclophosphamide, prednisolone

JOURNAL FREE ACCESS

1993 Volume 32 Issue 2 Pages 189-192

DOI https://doi.org/10.2169/internalmedicine.32.189

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Abstract

We describe a patient with Wegener's granulomatosis in whom the serum levels of interleukin-6 (IL-6) and other laboratory parameters were monitored. The IL-6 and CRP levels, which were extremely high before treatment, declined rapidly with corticosteroid and cyclophosphamide. IgG, leukocyte count and platelet count declined more gradually. Thus, determination of the serum IL-6 level might be useful in diagnosing and monitoring Wegener's granulomatosis.
(Internal Medicine: 32: 189-192, 1993)

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