Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Rhabdomyolysis and Acute Renal Failure in a Patient with Hypothyroidism
Nobuo SEKINEMichiko YAMAMOTOMakoto MICHIKAWATakeroh ENOMOTOMasaki HAYASHIEisuke OZAWATakayoshi KOBAYASHI
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JOURNAL FREE ACCESS

1993 Volume 32 Issue 3 Pages 269-271

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Abstract

A 61-year-old woman developed rhabdomyolysis and acute renal failure after strenuous walking. She had been treated for seven years with levothyroxine (T4) for hypothyroidism. On admission, her thyroid function test revealed marked hypothyroidism, suggesting poor drug compliance. Electromyographic and muscle biopsy findings were compatible with hypothyroid myopathy. Other diseases that could cause rhabdomyolysis were excluded. Her renal function completely recovered with peritoneal dialysis, and thyroid function normalized with 100μg/day of T4. The present case suggests that rhabdomyolysis could occur in patients with hypothyroidism, especially those with poor drug compliance, in combination with other aggravating factors such as exercise.
(Internal Medicine 32: 269-271, 1993)

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