Ulcerative Colitis in Female Siblings with an Identical Human Leukocyte Antigen Haplotype (A24, Bw52, DR52 and DQw1)

Kazuo AMANO; Akira SEKO; Hiroshi SUGIYAMA; Toshiaki TAKAHASHI; Tadashi WATANABE; Hisaya IGUCHI; Toshihiko NAGANO; Yukio OSUMI; Yoshiyuki FUWA; Koutaro NAGAI; Hisataka MORIWAKI; Yasutoshi MUTO

doi:10.2169/internalmedicine.32.298

Kazuo AMANO, Akira SEKO, Hiroshi SUGIYAMA, Toshiaki TAKAHASHI, Tadashi WATANABE, Hisaya IGUCHI, Toshihiko NAGANO, Yukio OSUMI, Yoshiyuki FUWA, Koutaro NAGAI, Hisataka MORIWAKI, Yasutoshi MUTO

Author information

Kazuo AMANO
the Department of Internal Medicine, Hashima City Hospital
Akira SEKO
the Department of Internal Medicine, Hashima City Hospital
Hiroshi SUGIYAMA
the Department of Internal Medicine, Hashima City Hospital
Toshiaki TAKAHASHI
the Department of Internal Medicine, Hashima City Hospital
Tadashi WATANABE
the Department of Internal Medicine, Hashima City Hospital
Hisaya IGUCHI
the Department of Internal Medicine, Hashima City Hospital
Toshihiko NAGANO
the Department of Internal Medicine, Hashima City Hospital
Yukio OSUMI
the Department of Internal Medicine, Hashima City Hospital
Yoshiyuki FUWA
the Department of Internal Medicine, Hashima City Hospital
Koutaro NAGAI
the Department of Internal Medicine, Hashima City Hospital
Hisataka MORIWAKI
the First Department of Internal Medicine, Gifu University School of Medicine
Yasutoshi MUTO
the First Department of Internal Medicine, Gifu University School of Medicine

Keywords: inflammatory bowel disease, familial occurrence

JOURNAL FREE ACCESS

1993 Volume 32 Issue 4 Pages 298-301

DOI https://doi.org/10.2169/internalmedicine.32.298

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Abstract

Two female siblings with ulcerative colitis are reported. Both the 30-year-old elder sister and the 28-year-old younger sister developed bloody stools and diarrhea; ulcerative colitis was diagnosed by endoscopic and histologic examination of the colon. Their maternal aunt also suffered from the disease. Human leukocyte antigen analysis revealed an identical haplotype for the sisters (A24, Bw52, DR2 and DQw1), while the aunt had A24, Bw52 and DR2. The haplotypes of Japanese patients with familial ulcerative colitis are reviewed, and the role of human leukocyte antigens in this disease is discussed.
(Internal Medicine 32: 298-301, 1993)

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