Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
A HTLV-I Carrier Who Showed Various Symptoms and Antibodies of Autoimmune Diseases
Masao MIZUKIShinichi TAGAWAMasaru SHIBANOYuji OKAMOTOJunzo NOJIMAKenmei SAKATAKiyoshi TAKATSUKISumio KAWATAMitsuo HASHIMOTOKozo HASHIMOTOYutaka ONOITakashi MACHIITeruo KITANI
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1993 Volume 32 Issue 6 Pages 449-454

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Abstract

We report a 37-year-old female HTLV-I carrier with complicating primary biliary cirrhosis (PBC) and mixed connective tissue disease (MCTD). Serum anti-HTLV-I antibody titer was ×256. Flower cells (4.5%) were found in the peripheral blood. Southern blot analysis showed no clonal integration in peripheral blood lymphocyte (PBL) DNA. Polymerase chain reaction showed the HTLV-I genome in PBLDNA. As cholestatic liver dysfunction and serum titer of anti-mitochondrial antibody were found, a clinical diagnosis of PBC was made. This patient later developed MCTD. These diseases responded well to prednisone. The pathogenetic relationship of HTLV-I infection with various autoimmune diseases is discussed.
(Internal Medicine 32: 449-454, 1993)

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