Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Circulating Abnormal Cells Detected in a Patient with Immunoblastic Lymphadenopathy
Taijiro ISHIYAMAKazuyuki WATANABEYoshihisa AKIMOTOHideyuki UENOKazunari YAMADAMichiaki KOIKEKen-ichiro HINOShigeru TOMOYASUNobuyoshi TUSRUOKAHidekazu OTA
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1993 Volume 32 Issue 6 Pages 455-458


An unusual case of immunoblastic lymphadenopathy (IBL) with circulating CD3-CD4+ cells is reported. A lymph node biopsy specimen showed the characteristic features of IBL. Two-color analyses demonstrated that the circulating abnormal cells were CD3-, CD4+, HLA-DR+, and CD25-. Chromosomal analysis revealed unrelated clones in the lymph node. Though 48% of the peripheral blood lymphocytes were abnormal, no clonal rearrangement of the TcR β chain gene was detected in the peripheral blood. This case might point out the possibility that some cases of IBL truly had no TcR gene rearrangement and were dysplasias.
(Internal Medicine 32: 455-458, 1993)

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