Direct Identification of Lung Cancer Cells Producing Granulocyte Colony Stimulating Factor with Monoclonal Anti-G-CSF Antibodies

Abstract

This is a case report of an 82-year-old man with squamous cell lung cancer which produced GCSF. The leukocyte cell count was elevated to 94, 400/mm³. The serum G-CSF concentration was also elevated to 351 pg/ml. This is the first report to demonstrate, by application of immunohistochemical staining techniques directly to tumor tissue obtained at autopsy, squamous carcinoma cells which produce G-CSF. The tumor cells were stained with monoclonal anti-G-CSF antibodies.
(Internal Medicine 32: 468-471, 1993)