Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Splenic Lymphoma with Villous Lymphocytes with CD5+, CDllc+ B-Cell Phenotype
Shuichi MIYAWAKITakashi MACHIIHisami HIRABAYASHIToru SAKURAHiroko SHIOZAKIKunihiko YASHIROHirokazu MURAKAMIJun TSUCHIYAKenji KASHIWABARATeruo KITANI
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1993 Volume 32 Issue 6 Pages 472-475

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Abstract

A 64-year-old male suffered from splenomegaly without lymphadenopathy. His WBC count on admission was 6.1×l09/l with 55% abnormal lymphocytes. No monoclonal gammopathy was detected. Abnormal cells shown in films usually had relatively abundant cytoplasm with serrated edges. Under phase-contrast microscopy, the cells displayed short, needle-like processes. The immunophenotype of peripheral blood mononuclear cells were CD19+, CD20+, CDllc+, FMC7+, CD5+, CD10-, CD25- and SIg+. The spleen histology showed a distinctive pattern of white pulp infiltration by abnormal lymphocytes with features of plasma cell differentiation. These findings were compatible with the features of splenic lymphoma with villous lymphocytes.
(Internal Medicine 32: 472-475, 1993)

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