Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Hypertrophic Cranial Pachymeningitis Associated with Mixed Connective Tissue Disease; A Comparison with diopathic and Infectious Pachymeningitis
Mika FUJIMOTOJun-ichi KIRAHiroyuki MURAITakeo YOSHIMURAKatsumi TAKIZAWAIkuo GOTO
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1993 Volume 32 Issue 6 Pages 510-512

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Abstract

This is the first report describing hypertrophic cranial pachymeningitis which developed in association with mixed connective tissue disease (MCTD).A 56-year-old man with a two-year history of MCTDgradually developed symptoms of headache and blurred vision. Bilateral papilledema and increased opening pressure and mild pleocytosis of the cerebrospinal fluid were noted. Magnetic resonance imaging of the brain revealed a diffuse thickening and a gadoliniumenhancement of the cranial dura mater. While five previous patients, diagnosed as idiopathic or infectious hypertrophic cranial pachymeningitis in our department, had either otitis media or sinusitis and showed multiple cranial nerve involvement, the present patient had neither otitis media nor sinusitis and did not show any cranial nerve involvement other than papilledema.
(Internal Medicine 32: 510-512, 1993)

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