Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Appropriate Interferon-alpha Therapy for Chronic Hepatitis C: An Assessment by Quantitative Changes in Serum Hepatitis C Virus-RNA
Shozo WATANABEYoshinao KOBAYASHIMasayoshi KONISHIMasato YOKOIRyuichi KAKEHASHIMasahiko KAITOShiro SUZUKI
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1993 Volume 32 Issue 7 Pages 523-529

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Abstract

The antiviral effect of natural interferon (IFN)-α on chronic hepatitis C virus (HCV) infection was estimated by determining quantitative changes in serum HCV-RNA compared with the serum alanine aminotransferase (sALT) improvement; the relationships of responses to IFN according to the dose and period of IFN therapy were defined to determine an appropriate IFN therapy protocol. Twenty-two patients with chronic hepatitis C were given natural IFN-α and in 16 (72.7%) patients the viraemia was suppressed during therapy. Five (27.7%) of them sustained the disappearance of HCV-RNA for more than 6 months after therapy accompanied with a prolonged sALT improve-ment. Pre-treatment viraemia levels in 5 complete responders with "complete suppression" of viraemia were significantly lower than in 11 patients with a transient loss or a decline of HCV-RNA. Afavorable antiviral response was closely associated with a high total dose of IFN-α and a long duration of IFN therapy.
(Internal Medicine 32: 523-529, 1993)

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