Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Integrin VLA-5 Negative Primary Plasma Cell Leukemia
Ken-ichi OHTAKETsutomu TAKEUCHIKeiko SAITOTatsuya ITOIsao ITOKazutoshi AOKIYasuhide TAKANOKoichi AMANOOsamu HOSONOJun KOIDEHiroshi SUZUKITohru ABE
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1993 Volume 32 Issue 7 Pages 565-568


We present a case of primary plasma cell leukemia with Bence Jones proteinuria. After combination chemotherapy, leukemic cells and the urinary levels Bence Jones protein were decreased. Small lytic bone lesions were detected only in the skull. Typical plasma cells were rarely seen in peripheral blood on the hyperleukocytic phase, however they were increased in the advanced stages. The most important diagnostic sign was persistent expression of CD38 antigen on leukemic cells throughout the entire course of the illness and these leukemic cells expressed very late antigen-4 (VLA-4) but not VLA-5.
(Internal Medicine 32: 565-568, 1993)

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