Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Acute Lymphoblastic Leukemia Associated with a t(l;19)(q23;pl3) in an Adult
Hitoshi OHNOTetsurou INOUETakashi AKASAKAAtsuko OKUMURASetsuko MIYANISHIIsao OHASHIMasahiko KIKUCHIMasahiro MASUYAHiroyuki AMANOTakanobu IMANAKAYoh-ichirou OHNO
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1993 Volume 32 Issue 7 Pages 584-587


A cytogenetic study of a 38-year-old patient with acute lymphoblastic leukemia (ALL) revealed a t(1;19)(q23;pl3), which is a characteristic translocation of childhood ALL. The leukemic cells were positive for the CD10, CD19, HLA-DR, TdT and cytoplasmic μ-chain. Both of the immunoglobulin heavy chain gene loci were rearranged and the RNA-based polymerase chain reaction demonstrated the E2A/PBX1 fusion transcript which is the result of the t(1;19). This finding suggests that the t(l;19) is implicated not only in childhood ALL but also in adult ALL patients.
(Internal Medicine 32: 584-587, 1993)

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