Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Marked Increase in Fundic Mucosal Histidine Decarboxylase Activity in a Patient with H+, K+-ATPase Antibody-Positive Autoimmune Gastritis
Yoshiji MIYAXAKIYasuhisa SHINOMURAYoko MURAYAMAIkuo IMAMURAHiroyuki FUKUIMasatomo MAEDAMasamitsu FUTAIYuji MATSUZAWA
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1993 Volume 32 Issue 7 Pages 602-606

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Abstract

A 63-year-old woman was diagnosed as autoimmune gastritis by the presence of serum antibody against α-subunit of gastric H+, K+-ATPase. The patient did not have pernicious anemia, but showed achlorhydria, marked hypergastrinemia, enterochromaffin-like cell hyperplasia and an extremely high histidine decarboxylase activity in the gastric fundic mucosa. Intragastric acidification by infusion of hydrochloric acid via a nasogastric tube induced a transient reduction of serum gastrin level and fundic mucosal histidine decarboxylase activity. A marked increase in fundic mucosal histidine decarboxylase activity as well as hypergastrinemia appears to be the pathophysiologic response to achlorhydria caused by autoimmunity against gastric H+, K+-ATPase.
(Internal Medicine 32: 602-606, 1993)

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