Successful Continuous Treatment with All-Trans Retinoic Acid for Acute Promyelocytic Leukemia; Secondary Malignancy after the Treatment of Osteosarcoma

Nadim MAHMUD; Tetsuya TSUKADA; Masanori TANIGUCHI; Takahiro TAKAHASHI; Hisakazu KIHIRA; Takao SEKINE; Hiroshi MIWA; Tohru KOBAYASHI; Kenkichi KITA; Katsumi DEGUCHI; Shigeru SHIRAKAWA

doi:10.2169/internalmedicine.33.654

Nadim MAHMUD, Tetsuya TSUKADA, Masanori TANIGUCHI, Takahiro TAKAHASHI, Hisakazu KIHIRA, Takao SEKINE, Hiroshi MIWA, Tohru KOBAYASHI, Kenkichi KITA, Katsumi DEGUCHI, Shigeru SHIRAKAWA

Author information

Nadim MAHMUD
The Second Department of Internal Medicine, Mie University School of Medicine
Tetsuya TSUKADA
The Second Department of Internal Medicine, Mie University School of Medicine
Masanori TANIGUCHI
The Second Department of Internal Medicine, Mie University School of Medicine
Takahiro TAKAHASHI
The Second Department of Internal Medicine, Mie University School of Medicine
Hisakazu KIHIRA
The Second Department of Internal Medicine, Mie University School of Medicine
Takao SEKINE
The Second Department of Internal Medicine, Mie University School of Medicine
Hiroshi MIWA
The Second Department of Internal Medicine, Mie University School of Medicine
Tohru KOBAYASHI
The Second Department of Internal Medicine, Mie University School of Medicine
Kenkichi KITA
The Second Department of Internal Medicine, Mie University School of Medicine
Katsumi DEGUCHI
The Second Department of Internal Medicine, Mie University School of Medicine
Shigeru SHIRAKAWA
The Second Department of Internal Medicine, Mie University School of Medicine

Keywords: etoposide, long complete remission

JOURNAL FREE ACCESS

1994 Volume 33 Issue 10 Pages 654-657

DOI https://doi.org/10.2169/internalmedicine.33.654

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Abstract

We report a rare case of complete remission for 32 months with continuous treatment with alltrans retinoic acid (ATRA) alone in a patient with acute promyelocytic leukemia which developed as a second malignancy after the treatment of osteosarcoma after failure of conventional chemotherapy. The adverse effects of ATRA were apparently tolerable.
(Internal Medicine 33: 654-657, 1994)

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