Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Effectiveness of Chemotherapy for Advanced Adenocarcinoma of the Pancreas in Combined Modality Therapy
Hiroyuki KATOHideyuki WAKASUGIMasaki YOKOTAMasayuki FURUKAWAToshio MUKUTAYukio YAMADAAkihiro FUNAKOSHI
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1994 Volume 33 Issue 3 Pages 142-146

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Abstract

Because it is difficult to diagnose at an early stage, pancreatic carcinoma is usually well advanced by the time it is diagnosed. The combined use of intraoperative radiotherapy, gastrointestinal and/or biliary tract bypass operation, celiac plexus nerve block, and chemotherapy is widely applied in treatment, with favorable results reported in some patients with advanced disease. To evaluate the efficacy of chemotherapy in such combinations, we compared the effect of 5-fluorouracil, its analogues, and mitomycin C on the survival of patients with advanced stage pancreatic cancer. We found no significant difference between the patients treated or not treated with these drugs. Clearly, there is a need for new agents having greater efficacy against pancreatic carcinoma.
(Internal Medicine 33:142-146, 1994)

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