Weekly Low-Dose Methotrexate Therapy for Sarcoidosis

Takafumi SUDA; Atsuhiko SATO; Mikio TOYOSHIMA; Shiro IMOKAWA; Atsushi YOSHITOMI; Ryoji TAMURA; Hideki SUGANUMA; Takeshi YAGI; Hiroshi HAYAKAWA; Masahiro SHIRAI; Kingo CHIDA

doi:10.2169/internalmedicine.33.437

Takafumi SUDA, Atsuhiko SATO, Mikio TOYOSHIMA, Shiro IMOKAWA, Atsushi YOSHITOMI, Ryoji TAMURA, Hideki SUGANUMA, Takeshi YAGI, Hiroshi HAYAKAWA, Masahiro SHIRAI, Kingo CHIDA

Author information

Takafumi SUDA
The Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine
Atsuhiko SATO
The Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine
Mikio TOYOSHIMA
The Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine
Shiro IMOKAWA
The Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine
Atsushi YOSHITOMI
The Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine
Ryoji TAMURA
The Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine
Hideki SUGANUMA
The Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine
Takeshi YAGI
The Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine
Hiroshi HAYAKAWA
The Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine
Masahiro SHIRAI
The Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine
Kingo CHIDA
The Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine

Keywords: refractory sarcoidosis, steroid-sparing effect

JOURNAL FREE ACCESS

1994 Volume 33 Issue 7 Pages 437-440

DOI https://doi.org/10.2169/internalmedicine.33.437

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Abstract

Low-dose methotrexate therapy has been used to treat a variety of chronic inflammatory diseases; a few studies have discussed the efficacy of this therapy for sarcoidosis. We present a patient with symptomatic sarcoidosis who was successfully treated with low-dose methotrexate after being refractory to steroids. This patient showed significant clinical improvement without development of any severe side effects. These findings suggest that low-dose methotrexate therapy may be a useful alternative treatment for sarcoidosis.
(Internal Medicine 33: 437-440, 1994)

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