Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Renal Thrombotic Microangiopathy in a Patient with Rheumatoid Arthritis and Antiphospholipid Syndrome: Successful Treatment with Cyclophosphamide Pulse Therapy and Anticoagulant
Masayo NOMURAJun OKADASumio TATENOYutaka KOBAYASHIHirobumi KONDO
Author information
JOURNALS FREE ACCESS

1994 Volume 33 Issue 8 Pages 484-487

Details
Abstract

A female patient with a history of migraines and chorea developed polyarthralgia at age 24 and was diagnosed with rheumatoid arthritis. In 1991 she was hospitalized because of impaired renal function and hypertension. Examination revealed thrombocytopenia and the presence of lupus anticoagulant. Antinuclear antibody was weakly positive, but anti-DNA antibody was negative, and no decrease in leukocyte count or complement level was observed. Rheumatoid arthritis with antiphospholipid syndrome was diagnosed. Renal biopsy showed renal thrombotic microangiopathy. This renal lesion was considered to be associated with antiphospholipid syndrome. Cyclophosphamide pulse therapy and anticoagulation therapy decreased proteinuria and improved renal function.
(Internal Medicine 33: 484-487, 1994)

Information related to the author
© The Japanese Society of Internal Medicine
Previous article Next article
feedback
Top