Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Acquired Idiopathic Pure Red Cell Aplasia in a Hemodialyzed Patient with Inactive Systemic Lupus Erythematosus
Hirokazu OKADAHiromichi SUZUKIHideo UCHIDAYoshihiko KANNOYuko KITAMURATadakazu HISAMATSUNobuhiro DEGUCHIDaisuke HAYASHITakao SARUTA
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1994 Volume 33 Issue 8 Pages 492-495

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Abstract

A male patient suffered chronic renal failure due to lupus nephritis and was undergoing hemodialysis. Six years after beginning hemodialysis, anemia developed, which improved by erythropoietin. Unresponsiveness to erythropoietin gradually appeared, and with a suspicion of pure red cell aplasia, he was treated with a high-dose corticosteroid but the unresponsiveness did not improve. Neither his serum nor lymphocytes inhibited erythropoiesis of either normal bone marrow stem cells or his own in vitro. These observations suggest an impaired hematopoietic microenvironment in his bone marrow.
(Internal Medicine 33: 492-495, 1994)

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