Thrombotic Thrombocytopenic Purpura and Myoglobinuric Acute Renal Failure following Radiation Therapy in a Patient with Polymyositis and Cervical Cancer

Hirofumi MAKINO; Yoshio NAGAKE; Kazuhiko MORIWAKI; Shuzo HIRAKAWA; Takaaki KATAYAMA; Hiroyuki YANAI; Kiyoshi TAKAHASHI; Tadaatsu AKAGI; Zensuke OTA

doi:10.2169/internalmedicine.34.24

Hirofumi MAKINO, Yoshio NAGAKE, Kazuhiko MORIWAKI, Shuzo HIRAKAWA, Takaaki KATAYAMA, Hiroyuki YANAI, Kiyoshi TAKAHASHI, Tadaatsu AKAGI, Zensuke OTA

Author information

Hirofumi MAKINO
the Third Department of Internal Medicine, Okayama University Medical School
Yoshio NAGAKE
the Third Department of Internal Medicine, Okayama University Medical School
Kazuhiko MORIWAKI
the Third Department of Internal Medicine, Okayama University Medical School
Shuzo HIRAKAWA
the Third Department of Internal Medicine, Okayama University Medical School
Takaaki KATAYAMA
Department of Gynecology and Obstetrics, Okayama University Medical School
Hiroyuki YANAI
the Second Department of Pathology, Okayama University Medical School
Kiyoshi TAKAHASHI
the Second Department of Pathology, Okayama University Medical School
Tadaatsu AKAGI
the Second Department of Pathology, Okayama University Medical School
Zensuke OTA
the Third Department of Internal Medicine, Okayama University Medical School

Keywords: rhabdomyolysis, myoglobinuria, acute tubular necrosis, microangiopathic hemolytic anemia

JOURNAL FREE ACCESS

1995 Volume 34 Issue 1 Pages 24-27

DOI https://doi.org/10.2169/internalmedicine.34.24

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Abstract

A 73-year-old woman was admitted to receive radiation treatment for uterine cervical cancer, however a complex series of events ensued, leading to death. She developed an acute exacerbation of polymyositis complicated by thrombotic thrombocytopenic purpura, rhabdomyolysis and acute renal failure. Radiation therapy may have produced an immune disturbance leading to the acute exacerbation of polymyositis. Auto-immune-mediated endothelial damage might have triggered a series of events leading to thrombotic thrombocytopenic purpura. Rhabdomyolysis seemed to be the main cause of acute renal failure.
(Internal Medicine 34: 24-27, 1995)

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