Big Insulin-like Growth Factor II-producing Hepatocellular Carcinoma Associated with Hypoglycemia

Shigeo ISHIDA; Mitsuhiko NODA; Nobuaki KUZUYA; Fumiyoshi KUBO; Shigeki YAMADA; Takeo YAMANAKA; Osamu ISOZAKI; Naomi HIZUKA; Yasunori KANAZAWA

doi:10.2169/internalmedicine.34.1201

Shigeo ISHIDA, Mitsuhiko NODA, Nobuaki KUZUYA, Fumiyoshi KUBO, Shigeki YAMADA, Takeo YAMANAKA, Osamu ISOZAKI, Naomi HIZUKA, Yasunori KANAZAWA

Author information

Shigeo ISHIDA
the Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School
Mitsuhiko NODA
the Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School
Nobuaki KUZUYA
the Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School
Fumiyoshi KUBO
the Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School
Shigeki YAMADA
the Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School
Takeo YAMANAKA
the Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School
Osamu ISOZAKI
the Second Department of Internal Medicine, Tokyo Women's Medical College
Naomi HIZUKA
the Second Department of Internal Medicine, Tokyo Women's Medical College
Yasunori KANAZAWA
the Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School

Keywords: non-islet cell tumor hypoglycemia (NICTH), insulin-like growth factor II (IGF-II) mRNA, hepatitis C virus (HCV)

JOURNAL FREE ACCESS

1995 Volume 34 Issue 12 Pages 1201-1206

DOI https://doi.org/10.2169/internalmedicine.34.1201

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Abstract

A 76-year-old female with a hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) was hospitalized because of fasting hypoglycemia. Her sera contained a low concentration of immunoreactive insulin and insulin-like growth factor (IGF)-I, while the IGF-II level was normal. However, most of the IGF-II consisted of the high molecular weight form (big IGF-II). The tumor tissue contained fetal type of IGF-II mRNA (6.0 kb). Furthermore, we found that one of the four patients examined with HCV-related HCC had big IGF-II in serum. This indicates that non-islet cell tumor hypoglycemia (NICTH) in HCV-related HCC might be accompanied by production of big IGF-II by the tumor.
(Internal Medicine 34: 1201-1206, 1995)

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