Renal Dysfunction in Multiple Myeloma

Abstract

This study aims to determine the clinical factors that may affect renal function and patient survival in 82 multiple myeloma patients. The patients were divided into 3 groups according to their renal function during the initial 8 weeks after diagnosis: Group 1, 54 patients with serum creatinine (S-Cr) <177 μmol/L; Group II, 11 with S-Cr≥177 μmol/L and receiving no dialysis; Group III, 17 undergoing dialysis treatment. Clinical status at diagnosis, subsequent renal function and patient survival were compared. Bence Jones proteinuria (BJP) was found in all patients in Groups II and III, compared to 67% of patients in Group I (p<0.05, I vs II or III). Hypercalcemia, hyperuricemia and intravenous administration of contrast medium, together with BJP each constituted independent risk factors of renal dysfunction. The incidence of hypercalcemia in Group II was significantly higher than in the other 2 groups. Patient survival was 26.8±23.7 months in Group I, 8.1±10.3 in II and 12.1±16.6 in III (p<0.05, I vs II or III). Renal function and patient survival depended on the initial renal function. Renal function was likely compromized in the presence of BJP.
(Internal Medicine 34: 364-370, 1995)