Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Urinary Albumin Fragments as a New Clinical Parameter for the Early Detection of Diabetic Nephropathy
Mitsunori YAGAMEDaisuke SUZUKIKiichiro JINDENaohiro YANORaita NAKAYoshifumi ABEYasuo NOMOTOHideto SAKAIHirokazu SUZUKIYoshitami OHASHI
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1995 Volume 34 Issue 6 Pages 463-468

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Abstract

Urinary albumin fragments (uAF) from patients with NIDDM were analyzed as a possible factor in the early discovery of diabetic nephropathy before emergence of microalbuminuria. SDS-PAGE and immunoblot assay were employed for detection of uAF. Samples from 252 patients with NIDDM, 158 patients with non-diabetic diseases, and 48 healthy volunteers were examined; uAF were detected in 139 (55.2%), 94 (59.5%), only one (2.1%), respectively. In diabetic patients with normoalbuminuria, uAF were detected in 48 out of 159 cases (30.2%). Two years after the initial study, 3 of the 17 diabetic patients (17.6%) with normoalbuminuria and uAF showed micro- or macroalbuminuria. It was concluded that detection of uAF might be useful for the early detection of diabetic nephropathy in NIDDM.
(Internal Medicine 34: 463-468, 1995)

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© The Japanese Society of Internal Medicine
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