Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Pulmonary Sarcoidosis: Pathogenesis and Population Differences
Sonoko NAGAI
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JOURNAL FREE ACCESS

1995 Volume 34 Issue 9 Pages 833-838

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Abstract

Sarcoidosis is a systemic disease. Clinical manifestations and prognosis are heterogeneous in sarcoidosis patients from various populations. This suggests that genetic factors and/or environmental factors seem to play important roles in the pathogenesis. Sarcoidosis is characterized as a hyperimmune response to unknown agent(s) at the lesion sites. Regarding pulmonary lesions, macrophage-T lymphocyte alveolitis precedes epithelioid cell granuloma formation. In this review, reports presented in international meetings were introduced to compare population differences; we attempted to review the issues which relate to disease susceptibility in patients with sarcoidosis. In addition, we discussed the possible causative agents, whether T cell receptor expression reflects antigen driven immune responses, and what type of biological active materials may be critical in determining the disease activity and/or prognostic factors, with particular focus on the population differences.
(Internal Medicine 34: 833-838, 1995)

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© The Japanese Society of Internal Medicine
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