Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Nephrogenic Diabetes Insipidus Induced by Lobenzarit Disodium Treatment in Patients with Rheumatoid Arthritis
Naoki SAKANEToshihide YOSHIDATsunekazu UMEKAWAReiko MIYAZAKIMotoharu KONDO
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JOURNAL FREE ACCESS

1996 Volume 35 Issue 2 Pages 119-122

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Abstract

Nephrogenic diabetes insipidus (NDI) occurred in a 43-year-old woman who had received lobenzarit disodium for the treatment of rheumatoid arthritis (RA). Her urine output was initially 3 ι/day and urine osmolarity was 203 mOsm/ι. Based on a sodium chloride loading test and a vasopressin loading test, she was diagnosed as having lobenzarit-induced NDI. Seven days after the cessation of the use of lobenzarit disodium, polydipsia and polyuria disappeared, and the vasopressin test showed a normal response. These findings suggest that lobenzarit induces a reversible form of NDI as a side effect. The reports of lobenzarit-induced NDI in Japan during the past seven years are also reviewed.
(Internal Medicine 35: 119-122, 1996)

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© The Japanese Society of Internal Medicine
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