Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Steroid Pulse Therapy in Lupus Cystitis
Chikako SEGAWATakashi WADAKengo FURUICHIKazuya TAKASAWAHitoshi YOKOYAMAKen-ichi KOBAYASHI
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JOURNALS FREE ACCESS

1996 Volume 35 Issue 2 Pages 155-158

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Abstract

A middle-aged woman with lupus cystitis showed no other symptoms of lupus vasculitis. Cystoscopic findings revealed mucosal hemorrhage and hyperemia. Histological studies of the bladder showed mucosal edema, inflammatory cellular infiltration and the deposition of immune complexes along the vessels. She was treated with a combination of intravenous methylprednisolone pulse therapy and oral prednisolone. Cystoscopy and histological findings showed appreciable improvement. Elevated urinary levels of chemokines such as interleukin-8 (IL-8) and monocyte chemotactic and activating factor (MCAF) decreased during convalescence. These results suggest that the early diagnosis and treatment with steroid pulse therapy achieves improvement of an unusual vasculitis symptom, lupus cystitis.
(Internal Medicine 35: 155-158, 1996)

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