Cyclic Cushing's Disease in Long-Term Remission with a Daily Low Dose of Bromocriptine

Masahiro ADACHI; Ryoichi TAKAYANAGI; Toshihiko YANASE; Yoshiyuki SAKAI; Shoichiro IKUYAMA; Hiroyuki NAKAGAKI; Yoshiyuki OSAMURA; Naoko SANNO; Hajime NAWATA

doi:10.2169/internalmedicine.35.207

Masahiro ADACHI, Ryoichi TAKAYANAGI, Toshihiko YANASE, Yoshiyuki SAKAI, Shoichiro IKUYAMA, Hiroyuki NAKAGAKI, Yoshiyuki OSAMURA, Naoko SANNO, Hajime NAWATA

Author information

Masahiro ADACHI
The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
Ryoichi TAKAYANAGI
The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
Toshihiko YANASE
The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
Yoshiyuki SAKAI
The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
Shoichiro IKUYAMA
The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
Hiroyuki NAKAGAKI
The Department of Neurosurgery, Shin Kokura Hospital
Yoshiyuki OSAMURA
The Department of Pathology, Tokai University School of Medicine
Naoko SANNO
The Department of Pathology, Tokai University School of Medicine
Hajime NAWATA
The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University

Keywords: antehypophysectomy, ACTH-positive microadenomas

JOURNAL FREE ACCESS

1996 Volume 35 Issue 3 Pages 207-211

DOI https://doi.org/10.2169/internalmedicine.35.207

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Abstract

A 56-year-old male patient with cyclic Cushing's disease remained in a state of remission for more than one year with a relatively low dose of bromocriptine (2.5-3.75 mg/day). It has been reported that bromocriptine treatment for cyclic Cushing's disease induces only a transient remission; in the most effective cases, a relatively high dose (40 mg/day) was necessary. In the hypercortisolemic state, plasma adrenocorticotropic hormone (ACTH) and serum cortisol were not suppressed by dexamethasone and did not respond to corticotropin-releasing factor (CRF). An antehypophysectomy was not effective, even though the resected tissue contained ACTH-positive microadenomas. The present observations thus indicate the effectiveness of bromocriptine for some patients with this rare disorder.
(Internal Medicine 35: 207-211, 1996)

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